Coronavirus (COVID-19)
Coronavirus disease (COVID-19) is an
infectious disease caused by a newly discovered coronavirus.
Most
people infected with the COVID-19 virus will experience mild to moderate
respiratory illness and recover without requiring special treatment.
Older people, and those with underlying medical problems like cardiovascular
disease, diabetes, chronic respiratory disease, and cancer are more likely to
develop serious illness.
The
best way to prevent and slow down transmission is be well informed about the
COVID-19 virus, the disease it causes and how it spreads. Protect yourself and
others from infection by washing your hands or using an alcohol based rub
frequently and not touching your face.
The
COVID-19 virus spreads primarily through droplets of saliva or discharge from
the nose when an infected person coughs or sneezes, so it’s important that you
also practice respiratory etiquette (for example, by coughing into a flexed
elbow).
Coronaviruses constitute the subfamily Orthocoronavirinae,
in the family Coronaviridae, order nidovirles, and
realm ribovirea. They are enveloped virus with a positive-sence
single standred RNA genome and a nucleocapsidof helical symmetry. The
genome size of coronaviruses ranges from approximately 27 to 34 kilobases,
the largest among known RNA vieuses The name coronavirus is
derived from the Latin corona, meaning "crown" or
"halo", which refers to the characteristic appearance reminiscent of
a crown or a solar corona around the virions (virus particles) when viewed
under two-dimensional transmission electron microscopy, due to the surface
being covered in club-shaped protein spikes.
The genome organization for a coronavirus is 5'-leader
UTR-replicase/transcriptase-spike (S)-envelope (E)-membrane (M)-nucleocapsid
(N)-3'UTR-poly (A) tail. The open reading frames 1a and 1b, which occupy the
first two-thirds of the genome, encode the replicase/transcriptase polyprotein.
The replicase/transcriptase polyprotein self cleaves to form the nonstructural
proteins (nsps).
The later reading frames encode the four major structural
proteins: spike, envelope, membrane, and nucleocapsid. Interspersed
between these reading frames are the reading frames for the accessory proteins.
The number of accessory proteins and their function is unique depending on the
specific coronavirus.
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